Product name: MK-677
Molecular Formula: C27H36N4O5S
Description: MK-677 is a highly effective oral growth hormone secretagogue designed to enhance growth hormone secretion in subjects resulting in all the benefits that come with this important hormone including muscle growth, repair and performance capabilities. It is currently under development as one of the most effective oral growth hormone compounds discovered to date.
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Elite Scientific Analysis:
MK-677 (Ibutamoren) is a long-acting, orally-active, and selective agonist of the ghrelin receptor. It is a growth hormone secretagogue which mimics the growth hormone stimulating action of the natural hormone ghrelin. Essentially this compound is able to enhance natural growth hormone secretion in subjects resulting in all the benefits that come with this important hormone including muscle growth, repair and performance capabilities.
Initially developed for use as a treatment for muscle wasting, obesity and osteoporosis MK677 has been demonstrated to increase the release of several other hormones including insulin-like growth factor 1 without affecting cortisol levels and been shown to sustain activation of the GH-IGF-1 Axis and increase lean body mass with no change in total fat mass or visceral fat. Over 12 months it enhanced growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated amongst the 65 patients in a 2008 clinical study.
The results indicate that long-term functional and pharmacoeconomic studies in elderly persons could be beneficial.
MK-677 works by increasing the release of growth hormone, amplifying the signalling in somatotropic cells in the pituitary gland, inhibiting the natural release of somatostatin, and inhibiting somatostain receptor signal pathways. All of these activities result in either a net gain in natural growth hormone or an increase in growth hormone potency.
As such the MK677 compound has significant potential as a growth hormone supplement and is currently under development as a therapy for building muscle mass and aiding in recovery after surgery.
Copinschi G., Van Onderbergen A., L'Hermite-Balériaux M., Mendel C.M., Caufriez A., Leproult R., Bolognese J.A., De Smet M., Thorner M.O., Van Cauter E., Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men, Journal of Clinical Endocrinology and Metabolism, 1996, 81(8), 2776-2782.
Nass R., Pezzoli S.S., Oliveri M.C., Patrie J.T., Harrell F.E. Jnr, Clasey J.L., Heymsfield S.B., Bach M.A., Vance M.L. Thorner M.O., Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults, Ann Intern Med, 2008, 149(9), 601-611.
Murphy M.G., Bach M.A., Plotkin D., Bolognese J., Ng J., Krupa D., Cerchio K., Gertz B.J., Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group., Journal of Bone and Mineral Research, 1999, 14(7), 1182–1188.
Murphy M.G., Weiss S., McClung M., Schnitzer T., Cerchio K., Connor J., Krupa D., Gertz B.J., Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women, Journal of Clinical Endocrinology and Metabolism, 2001, 86(3),1116–1125.